David Sacks’ prediction on All-In E67 was that the emerging trucker/mandate protests signaled a working‑class vs. professional‑class schism inside the Democratic coalition, and that if Biden didn’t handle this trucker/mandate issue correctly, it would be “the end of his presidency.”(transcriptize.com)

What actually happened:

• The U.S. “People’s Convoy” modeled on Canada’s Freedom Convoy drove loops around the D.C. Beltway in March 2022 but caused only minor slowdowns, failed to significantly disrupt Washington, and never re‑entered D.C. as planned. By May 20, 2022, organizers officially disbanded the convoy after achieving essentially no concrete policy concessions.(thenationalnews.com) The issue faded from national attention.
• Biden initially extended the COVID national emergency in early 2022, but over 2022–23 most federal and state COVID restrictions and mandates were wound down; the convoy itself did not force a dramatic turning point in his stance.(upi.com)
• Biden’s presidency ended after one term because he withdrew from the 2024 race in July 2024 amid doubts about his age and electability, and Republicans won back the White House when Donald Trump defeated Kamala Harris in November 2024.(en.wikipedia.org)
• Analyses of the 2022 midterms, 2024 election, and Biden’s approval ratings consistently identify inflation, cost of living, the broader economy, immigration, and general performance as the dominant reasons for his political weakness—not COVID mandates or the 2022 trucker convoy.(en.wikipedia.org)

So while Biden did leave office after a single term, there is no evidence that his handling of the U.S. trucker convoy or related COVID‑mandate protests was what “ended his presidency” or politically crippled him. The convoy quickly fizzled and was not a lasting or central factor in his downfall. That makes Sacks’ conditional prediction—framed around this specific issue—wrong.