As of 2025, only 25 years of the 21st century have passed, and the prediction is explicitly about trends "this century" and especially conditions "by the end of the century." Whether biomanufacturing will become the primary production method for many of the molecules used in food, clothing, and materials by ~2100 cannot yet be determined.

What we can say so far:

• Biomanufacturing and industrial biotechnology have indeed grown rapidly in the U.S. and globally since 2020, with significant investment in areas like precision fermentation, synthetic biology, and bio-based materials (e.g., alternative proteins and bio-based textiles). These trends are consistent with the direction of the prediction, but they do not yet establish that biomanufacturing will become the primary production method by century’s end.
• Competing and complementary technologies (petrochemical processes, conventional agriculture, advanced chemistry, and new material-science techniques) are still dominant for most food, clothing, and materials production as of 2025.

Because the core claim is about the ultimate dominance of biomanufacturing by the end of the 21st century, and that date has not arrived yet, it is too early to judge it as right or wrong. The observable partial alignment (rapid growth of biomanufacturing) is not enough to definitively confirm the long‑term outcome.

Therefore the prediction’s status as of November 29, 2025 is: inconclusive (too early to tell).