As of 2025, the deadline for this prediction ("over this century" / before 2100) is still far in the future—around 75 years remain. The claim is that one or more extremely large technological breakthroughs (on the order of 100x–10,000x improvements) will occur and will resolve many of humanity’s major challenges on Earth (energy, climate, health, resources).

While there have been major advances since 2021—e.g., rapid progress in renewable energy and falling solar and battery costs, mRNA vaccine platforms, and ongoing work in nuclear fusion and AI—none of these has yet clearly achieved a 100x–10,000x step-change that resolves most of the cited global challenges in a widely accepted way. Climate change remains a major concern, global health burdens are still substantial, and resource constraints are not considered solved by mainstream expert assessments.

Because:

1. The prediction’s time horizon is up to 2100, and
2. The specific condition (dramatic breakthroughs that resolve most major challenges) has not clearly been met yet, and
3. There is still ample time for it to become true or remain false,

it is too early to judge the prediction as right or wrong.

Therefore the correct status is: it cannot yet be determined whether this prediction will come true.